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Coordination of the CCQM-P20 series of comparisons
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SI traceable measurements
Coordination of the CCQM-P20 series of comparisons
Analytes under study
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The BIPM is coordinating the ongoing CCQM-P20 series of comparisons related to organic substance purity determination, and has established laboratory facilities to support these activities. The facilities* include LC/UV, LC/MS, GC/MS, GC/FID and DSC, Karl Fischer titration and thermogravimetric analysis instrumentation.

The CCQM initiated CCQM-P20, a series of pilot studies carried out within the CCQM Organic Analysis Working Group (OAWG), to compare and demonstrate the degree of equivalence of national measurement capabilities for purity determination.

The overall aim of the series of studies is to evaluate the scope, applicability and limitations of various methodologies to assess the purity of organic materials. This will allow a comprehensive series of guidelines to be developed for the design of purity assessment plans appropriate for a given organic compound or compound chemical class for use in a given measurement application. Additionally, these studies allow NMIs to assess their capabilities to characterize the purity of their own materials, including the quantification of specific impurities, and to determine the contribution that different sources of material can have on the degree of equivalence determined in CCQM comparisons. They also allow NMIs with specific CMC claims for the provision of organic pure substance Certified Reference Materials (CRMs) to demonstrate their purity assignment capabilities.


* LC/UV: liquid chromatography/ultraviolet spectroscopy
LC/MS: liquid chromatography/mass spectrometry
GC/MS: gas chromatography/mass spectrometry
GC/FID: gas chromatography/flame ionization detection
DSC: differential scanning calorimetry